In a study published in the Journal of Research in Medical Science, the scientists of the Center for Biochemistry and Nutrition in Metabolic Diseases of the Kasham University made some very interesting considerations related to melatonin and the reduction of oxidative stress:
Free radicals are atoms or molecules with unpaired electrons which make them highly attractive to other molecules. Free radicals which are called ROS can cause oxidative stress and damage to cell components. Increased production of ROS can cause oxidative damages to organs, tissues, and various cells such as brain, heart, and vascular cells. Oxidative stress is also the background of many hard diseases such as high blood pressure atherosclerosis and infectious diseases Melatonin has been shown to possess high level of antioxidant activity and the ability to counteract with oxidative stress-induced diseases, even in most of clinical trials Melatonin is the stimulator of antioxidant enzymes including superoxide dismutase, GPx, GSH reductase, and catalase. It also acts as inhibitor of lipoxygenase. Therefore Melatonin can cause resistance to oxidation damage.